@article{hempel_impact_2022,
	title = {The {Impact} of {Pancreatic} {Head} {Resection} on {Blood} {Glucose} {Homeostasis} in {Patients} with {Chronic} {Pancreatitis}},
	volume = {11},
	issn = {2077-0383},
	url = {https://www.mdpi.com/2077-0383/11/3/663},
	doi = {10.3390/jcm11030663},
	abstract = {Background: Chronic pancreatitis (CP) often leads to recurrent pain as well as exocrine and/or endocrine pancreatic insufficiency. This study aimed to investigate the effect of pancreatic head resections on glucose metabolism in patients with CP. Methods: Patients who underwent pylorus-preserving pancreaticoduodenectomy (PPPD), Whipple procedure (cPD), or duodenum-preserving pancreatic head resection (DPPHR) for CP between January 2011 and December 2020 were retrospectively analyzed with regard to markers of pancreatic endocrine function including steady-state beta cell function (\%B), insulin resistance (IR), and insulin sensitivity (\%S) according to the updated Homeostasis Model Assessment (HOMA2). Results: Out of 141 pancreatic resections for CP, 43 cases including 31 PPPD, 2 cPD and 10 DPPHR, met the inclusion criteria. Preoperatively, six patients (14\%) were normoglycemic (NG), 10 patients (23.2\%) had impaired glucose tolerance (IGT) and 27 patients (62.8\%) had diabetes mellitus (DM). In each subgroup, no significant changes were observed for HOMA2-\%B (NG: p = 0.57; IGT: p = 0.38; DM: p = 0.1), HOMA2-IR (NG: p = 0.41; IGT: p = 0.61; DM: p = 0.18) or HOMA2-\%S (NG: p = 0.44; IGT: p = 0.52; DM: p = 0.51) 3 and 12 months after surgery, respectively. Conclusion: Pancreatic head resections for CP, including DPPHR and pancreatoduodenectomies, do not significantly affect glucose metabolism within a follow-up period of 12 months.},
	language = {en},
	number = {3},
	urldate = {2022-05-12},
	journal = {Journal of Clinical Medicine},
	author = {Hempel, Sebastian and Oehme, Florian and Ehehalt, Florian and Solimena, Michele and Kolbinger, Fiona and Bogner, Andreas and Welsch, Thilo and Weitz, Jürgen and Distler, Marius},
	month = jan,
	year = {2022},
	keywords = {WP5},
	pages = {663},
}